Studies on Marek's Disease Tumor-associated Surface Antigen
نویسنده
چکیده
منابع مشابه
Development and characterization of monoclonal antibodies to Marek's disease tumor-associated surface antigen.
Four monoclonal antibodies, A35, B94, EB29, and G152, against Marek's disease tumor-associated surface antigen have been developed and their specificities studied against a panel of Marek's disease and lymphoid leukosis primary tumors; Marek's disease, and lymphoid leukosis, and reticuloendotheliosis lymphoblastoid cell lines; and normal chicken cells. A35 and G152 are of the immunoglobulin M c...
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Capping of chicken major histocompatibility (MHC) antigens on normal thymus, spleen, and peripheral blood leukocytes was demonstrated, although MHC antigens appeared to be present on only 15 to 18% of normal thymus cells. MHC antigen capping also occurred on cells from a Marek's disease herpesvirus-induced transplantable lymphoma (MDCT-NYM1). Capping of a Marek's disease tumor-associated surfac...
متن کاملDifferentiation properties of avian tumor cell lines: analysis using chicken fetal antigen and other markers.
Three avian lymphoblastoid tumor cell lines were compared for the expression of the serologically complex cell surface antigen, chicken fetal antigen (CFA), and other properties associated with differentiation. Two Marek's disease cell lines (CU-12 and CU-36) and a cell line associated with lymphoid leukosis (CU-10) were all found to differ qualitatively in the expression of CFA. While both Mar...
متن کاملSurface antigens on Marek's disease lymphoblastoid tumor cell lines.
A total of 32 Marek's disease virus (MDV)-induced cell lines, 1 avian leukosis virus-induced cell line, and 1 reticuloendotheliosis virus (REV)-induced lymphoblastoid cell line were investigated for the presence of Fc receptors, surface IgM, and Ia-like antigen. Surface IgM and Fc receptors could not be demonstrated on any of the cell lines. Ia-like antigen was detected on all MDV-induced cell ...
متن کاملMonoclonal antibody to chicken fetal antigen on Marek's disease lymphoblastoid cell line MDCC-MSB1.
A monoclonal antibody (2H3) to chicken fetal antigen (CFA) expressed on the cell surface of the Marek's disease lymphoblastoid cell line MDCC-MSB1 was generated. 2H3 reacted specifically with various cells from chicken embryos, especially with fetal red blood cells, fetal bursa-derived lymphocytes, fetal liver cells, and embryo fibroblasts but not with fetal peripheral blood lymphocytes. 2H3 re...
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